“Discover how azelastine nasal spray help prevent COVID infection risk by up to two-thirds. Learn study results, safe use tips, and why more research is needed
COVID still spreads quietly.
Vaccines help a lot.
But new research shows a simple nasal spray might help too.
That spray is azelastine.
It is an allergy medicine you can buy at the store.
Could it also prevent COVID infections?
A small clinical trial says yes.
But more proof is needed.
This guide explains the findings.
You get clear, simple answers.
Let’s dive in.
What Is Azelastine Nasal Spray?
Azelastine is an antihistamine.
It blocks allergy symptoms.
You spray it in your nose.
It works within about an hour.
Packages often carry names like Astelin.
It reduces sneezing, itching, and runny nose.
It has been safe for years.
Some side effects are mild, like bitter taste or headache.
It is OTC (over the counter) in the U.S.
🌿 Azelastine Nasal Spray
Azelastine nasal spray is a medicine that many people use for allergy relief.
It belongs to a group of drugs called antihistamines.
These drugs block histamine, a chemical your body makes when it reacts to allergens.
Histamine causes symptoms like sneezing, runny nose, and itchy eyes.
When you spray azelastine in your nose, it works directly where allergies hit.
It acts fast.
Some people feel relief in about 15 minutes.
This makes it a good choice for people who need quick help.
Azelastine is often sold under brand names like Astelin or Astepro.
In the United States, you can buy some versions without a prescription.
This makes it easy to find at most pharmacies.
✅ What It Helps With
Azelastine spray is mainly used for:
- Seasonal allergies like pollen or grass
- Year-round allergies like dust or pet dander
- Non-allergic rhinitis, where the nose runs but not from allergies
It reduces sneezing, runny nose, and nasal congestion.
It also helps reduce nasal itching.
âš Side Effects
Like all medicines, azelastine can cause side effects.
The most common ones are:
- A bitter taste in the mouth
- Mild headache
- Sleepiness
- Nose irritation
These are usually mild and go away with time.
Most people tolerate the spray well.
💡 How to Use
Use the spray exactly as the package or doctor says.
Usually, adults spray one or two sprays in each nostril twice a day.
Shake the bottle before use.
Blow your nose gently.
Spray while keeping your head upright.
Avoid spraying directly into the eyes.
🧪 Research Beyond Allergies
Recent studies show azelastine may have antiviral effects.
Some researchers are exploring whether it can lower the risk of viral infections, including COVID-19.
Early results are promising, but more trials are needed before official approval.
Azelastine nasal spray is safe, effective, and easy to use.
It is trusted for allergy relief and may offer more benefits in the future.
If you have frequent allergy symptoms, ask your doctor if this spray is right for you.
Can Azelastine Nasal Spray Help Prevent COVID Infection?
A recent phase 2 clinical trial tested its use as a preventive measure.
This study is published in JAMA Internal Medicine.
Study Highlights:
- 450 healthy adults enrolled at Saarland University in Germany.
- Half used azelastine spray three times daily for 56 days.
- Half used a placebo spray on the same schedule.
- COVID-19 infections confirmed via PCR.
Key Results:
- Only 2.2% in the azelastine group got infected.
- 6.7% in the placebo group got infected.
- That’s about a 67% reduction in risk.
Also:
- Fewer symptomatic COVID cases.
- Fewer rhinovirus (common cold) infections too.
- Time until infection was longer for the azelastine group.
These results are promising.
They show azelastine might block virus entry in the nose.
How It Might Work
Azelastine may block the virus’s entry or replication.
Lab studies (in vitro) show antiviral effects.
It may bind to ACE2 or affect viral proteins.
Because the nose is a main entry for COVID, a nasal spray could reduce infection early.
Why This Study Matters
It is the first human trial to show real-world prevention.
The spray is cheap, accessible, and already approved.
Imagine using it in addition to masks, vaccines, and hygiene.
But this is an early study.
We need bigger, multi-country trials before doctors can recommend it widely.
What Experts Say
Prof. Robert Bals, lead of the study, notes it is a practical tool.
But he urges more research first.
Dr. Dan Barouch reminds us that phase 2 results are not final.
Yet, the reduction seen is significant.
He encourages larger trials.
They agree: positive, but not conclusive.
What This Means for You
If you already use azelastine for allergies, it may provide extra protection.
But do not rely on it alone.
Vaccination and masks remain key.
Only use it as a possible bonus, not a replacement.
Safety and Side Effects
Azelastine is generally safe.
Few side effects: bitter taste, mild headache, sleepiness.
In the study, side effects were similar in both azelastine and placebo groups.
No major safety concerns were noted.
Still, people who are pregnant or have health concerns should ask a doctor first.
How to Use It (Based on Study)
In the trial, azelastine 0.1% spray was used.
Spray twice daily in each nostril.
Use for up to 8 weeks.
Note: That’s what the study did.
Always follow the product label for regular use.
FAQs
Q1. Does azelastine replace COVID vaccination?
No. Vaccines are still the best defense.
Q2. Can I buy azelastine over the counter?
Yes. It’s available in many pharmacies.
Q3. Is it approved to prevent COVID?
Not yet. The study is a first step.
Q4. Is it safe for kids or the elderly?
We need more data. Ask a doctor first.
Q5. Are there other nasal sprays for COVID?
Early studies show steroids may reduce severe COVID.
But they are not proven for prevention yet.
Trusted External Source
For more detailed info, read the full trial published by JAMA Internal Medicine:
👉 JAMA Internal Medicine article on azelastine nasal spray
Final Thoughts
Azelastine nasal spray shows real promise in preventing COVID infection.
It cut risk by about two-thirds in a well-designed trial.
It’s safe, easy to use, and available now.
Still, this should not replace vaccines or masks.
Think of it as another layer of defense.
But experts must confirm results before official recommendations.
Stay informed. Stay safe.
Science is moving fast—and every tool helps.